| Sayam | The time of the late evening. |
| Sayed | A master or a noble descendant. |
| Sayeeda | A leader or a noble woman. |
| Seema | Boundary; Border; Limit; Limit.; Limit, border; Sprout; A Sign; A symbol; a sign |
| Seemanta | Parting line of hair |
| Seemanti | A woman with a parting line |
| Seemantini | A lady with a hair parting |
| Seerat | Inner beauty; fame |
| Sejal | Pure; Depth in character; River water |
| Selina | Lunar Glow; Moon; Moon goddess.; Star in the sky; Variant of Celine: French form of the Latin caelum meaning sky or heaven. Also a variant of Celia or Selena. |
| Selma | Comely; Devine Protector; Divine helmet. A feminine derivative of Anselm.; Feminine diminutive of Anselm: Gods helmet.; Fair; Secure.; Variant of Salma: Peaceful. Pacifist. |
| Selvakumaran | A prosperous young man. |
| Selvan | A wealthy or prosperous man. |
| Semanti | A name meaning a fragrant flower. |
| Senajit | Conquerer of an army; Victory over army |
| Sendhil | God Murugan; also Sendil; Lord Murugan |
| SendhilNathan | The lord of the redhued god Murugan. |
| Sengannan | A name meaning one with reddish eyes. |
| Senmal | A name of unknown origin. |
| Senthamarai | A beautiful red lotus flower. |
| Serena | Calm; tranquil.; Having a peaceful disposition; Quiet; Quiet calm; Serene; Serene, Calm |
| Sevak | A dedicated humble servant |
| Sevati | Resembling the white rose; White rose |
| Sevita | A name meaning cherished one. |
| Shaan | Peaceful.; A peaceful man; Prestige; Dignity; Pride; Pride |
| Shabab | Refers to youth or prime of life. |
| Shabalini | One who is like a lotus flower. |
| Shabana | Belonging to night. Young lady.; Decorated; A maiden belonging to the night; Young lady |
| Shabari | A tribal devotee of Lord Rama |
| Shabnam | The delicate dew of the morning. |
| Shabnum | It refers to the morning dew. |
| Shachi | Wife of Lord Indra; Wife of Indra, intelligence |
| Shachin | It means pure or existence. |
| Shadab | It means fresh and blooming. |
| Shagufta | Blooming. Flourishing.; Flowering |
| Shahalad | One who brings great joy |
| Shahana | A beautiful royal princess |
| Shaheen | A royal white falcon or hawk. |
| Shaheena | Tender; Variant of Shahina: Falconess. |
| Shahid | A martyr (religious or political); Patriot |